CYP716A83

Centella asiatica CYP716A

Apiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

α-amyrin

PubChem ↗ C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C…

CYP716A83

ΔMass: +29.9742 Da methyl_to_carboxyl(+29.9742)

Product

ursolic acid

PubChem ↗ C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; C-28 oxidase; catalyzes oxidation at C-28 position of pentacyclic triterpenoid skeleton to produce ursolic acid; confirmed by heterologous expression in S. cerevisiae with product detection.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Terpenoids
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:41799686 ↗
DOI: 10.1016/j.synbio.2026.01.030 ↗
UniProt: A0A1I9Q5Y4 ↗
GenBank: —
NCBI TaxID: 48106 ↗

Modular reconstruction and multilevel regulation of <i>Saccharomyces cerevisiae</i> to drive the efficient synthesis of asiatic acid.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme