CYP76AH3

Salvia miltiorrhiza CYP76A

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

ferruginol

PubChem ↗ CC(C)C1=C(C=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)O

CYP76AH3

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

11-hydroxyferruginol

PubChem ↗ CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; 文献中SmCYP76AH3被列为tanshinone生物合成核心基因，催化ferruginol羟基化生成11-hydroxyferruginol，基于qRT-PCR表达上调及已知通路推断。

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41624420 ↗
DOI: 10.1093/hr/uhaf249 ↗
UniProt: A0A0Y0GRS3 ↗
GenBank: —
NCBI TaxID: 226208 ↗

CRISPR/Cas9-mediated uORF engineering enhances tanshinone biosynthesis in <i>Salvia miltiorrhiza</i>.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme