CYP719A39

Corydalis yanhusuo CYP719A

Papaveraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-scoulerine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O

CYP719A39

ΔMass: -4.0313 Da mismatch

Product

(S)-stylopine

PubChem ↗ C1CN2CC3=C(C[C@H]2C4=CC5=C(C=C41)OCO5)C=CC6=C3OCO6

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; De novo production in engineered yeast strain XJ0695 co-expressing CyCYP719A39 and CyCYP719A42; yield 32 mg/L.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:36737755 ↗
DOI: 10.1186/s12934-023-02024-2 ↗
UniProt: —
GenBank: —
NCBI TaxID: 458692 ↗

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme