CYP719A39

Corydalis yanhusuo CYP719A

Papaveraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

(S)-scoulerine

PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O

CYP719A39

ΔMass: -2.0157 Da ketone_formation(-2.0157)

Product

(S)-cheilanthifoline

PubChem ↗ COC1=C(C=C2[C@@H]3CC4=C(CN3CCC2=C1)C5=C(C=C4)OCO5)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Catalyzes methylenedioxy bridge-formation on D ring; high conversion rate >90%.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
PDF audit quarantine (enzyme_miss_in_pdf;two_core_fields_in_text;review_structured_partial_core). pdf=36737755.pdf; enzyme_in_pdf=miss; issue=review_structured…
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:36737755 ↗
DOI: 10.1186/s12934-023-02024-2 ↗
UniProt: —
GenBank: —
NCBI TaxID: 458692 ↗

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme