CYP726A27

Euphorbia lathyris CYP726A

Euphorbiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

casbene

PubChem ↗ C/C/1=C\CC/C(=C/C2C(C2(C)C)CC/C(=C/CC1)/C)/C

CYP726A27

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

5-hydroxycasbene

PubChem ↗ C/C/1=C\CC/C(=C/CC(/C(=C/[C@@H]2[C@@H](C2(C)C)CC1)/C)O)/C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP726A27 catalyzes regio-specific 5-oxidation of casbene; confirmed by in vitro microsomal assays and in vivo N. benthamiana expression.

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:27506796 ↗
DOI: 10.1073/pnas.1607504113 ↗
UniProt: KR350669 ↗
GenBank: KR350669 ↗
NCBI TaxID: 212925 ↗

Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme