Gold
ΔMass ✓
Other
Substrate reaction site
Product reaction site
MCS substructure diff highlighting · RDKit atom mapping
Evidence trail
Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.
Source text excerpt Other; Other; De novo synthesis of costunolide in engineered yeast expressing LsCOS; spontaneous lactonization after 6β-hydroxylation.
Reaction & quality gates
- Mechanism
- Ketone formation (-2.02 Da)
- Evidence type
- In vivo
- Confidence
- High
- Data tier
- Gold
Latin binomial + experiment + dual SMILES + ΔMass pass - Substrate class
- Organic acids
- Product class
- Terpenoids
Literature & public identifiers
- PubMed
- PMID:21515683 ↗
- DOI
- 10.1074/jbc.m110.216804 ↗
- UniProt
- F8S1I0 ↗
- GenBank
- —
- NCBI TaxID
- 4236 ↗
Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.