HPO

Hyoscyamus muticus CYP71D

Solanaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

solavetivol

PubChem ↗ C[C@@H]1C[C@@H](C=C([C@]12CC[C@H](C2)C(=C)C)C)O

HPO

ΔMass: -2.0157 Da ketone_formation(-2.0157)

Product

solavetivone

PubChem ↗ C[C@@H]1CC(=O)C=C([C@]12CC[C@H](C2)C(=C)C)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; HPO catalyzes second oxidation of solavetivol to solavetivone; evidence from time-course and kinetic studies.

Reaction & quality gates

Mechanism: Ketone formation (-2.02 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:17715131 ↗
DOI: 10.1074/jbc.m703378200 ↗
UniProt: A6YIH8 ↗
GenBank: —
NCBI TaxID: 35626 ↗

Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme