ZjuNMT

Ziziphus jujuba

Rhamnaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

cyFPIY-dc (decarboxylated cyclic FPIY peptide)

PubChem ↗ COc1cc2c(cc1O)CC[N+](C)(C)[C@@H]2Cc1ccc(O)cc1

ZjuNMT

ΔMass: +0.0000 Da mismatch

Product

lotusine A (N,N-dimethylated cyFPIY-dc)

PubChem ↗ COc1cc2c(cc1O)CC[N+](C)(C)[C@@H]2Cc1ccc(O)cc1

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; SAM-dependent N-methyltransferase; in vitro reaction with purified ZjuNMT and SAM; NMR confirmed lotusine A.

Reaction & quality gates

Mechanism: Other
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41698050 ↗
DOI: 10.1021/jacs.5c23400 ↗
UniProt: PV929270 ↗
GenBank: PV929270 ↗
NCBI TaxID: 326968 ↗

Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme