CYP76AK18

Salvia canescens CYP76A

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

11-hydroxyferruginol

PubChem ↗ CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)O)O

CYP76AK18

ΔMass: +29.9742 Da methyl_to_carboxyl(+29.9742)

Product

carnosic acid

PubChem ↗ CC(C)C1=C(C(=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C(=O)O)O)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; ScCYP76AK18 from Salvia canescens; successive oxidation to carboxylation at C-20.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:37542034 ↗
DOI: —
UniProt: A0A6G5RTF3 ↗
GenBank: —
NCBI TaxID: 3110500 ↗

Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme