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Quarantine mismatch Cyclization

PpOSC1

Paris polyphylla

Melanthiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
2,3-oxidosqualene
PubChem ↗ CC(=CCC/C(=C/CC/C(=C/CC/C=C(\C)/CC/C=C(\C)/CCC1C(O1)(C)C)/C)/C)C
PpOSC1
ΔMass: +0.0000 Da mismatch
Product
cycloartenol
PubChem ↗ C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; Functional verification in N. benthamiana and yeast; GC-MS confirmed cycloartenol production.

Reaction & quality gates

Mechanism
Cyclization
Evidence type
In vivo
Confidence
High
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:35027659 ↗
DOI
10.1038/s42003-022-03000-z ↗
UniProt
GenBank
NCBI TaxID
49666 ↗

Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla.