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Quarantine mismatch Other

CHS

Solanum lycopersicum

Solanaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
3-HAA methyl ester
PubChem ↗ COC(=O)c1cccc(O)c1N
CHS
ΔMass: +0.0000 Da mismatch
Product
coumaroyl anthranilate amide
PubChem ↗ COC(=O)c1cccc(O)c1N

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt Other; Other; SlCHS catalyzes amide bond formation between 3-HAA methyl ester and p-coumaroyl-CoA, producing coumaroyl anthranilate amide (3). In vitro assay with purified enzyme confirmed activity.

Reaction & quality gates

Mechanism
Other
Evidence type
In vitro
Confidence
High
Data tier
Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class
Other
Product class
Other

Literature & public identifiers

PubMed
PMID:33127687 ↗
DOI
10.1126/sciadv.abd1143 ↗
UniProt
P23418 ↗
GenBank
NCBI TaxID
4081 ↗

Discovery of a previously unknown biosynthetic capacity of naringenin chalcone synthase by heterologous expression of a tomato gene cluster in yeast.