CYP728D25

Salvia divinorum CYP728D

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

hardwickiic acid

PubChem ↗ C[C@@H]1CC[C@@]2([C@@H]([C@]1(C)CCC3=COC=C3)CCC=C2C(=O)O)C

CYP728D25

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

divinatorin A

PubChem ↗ C[C@@H]1CC[C@@]2([C@@H]([C@@]1(C)CCC3=COC=C3)[C@H](CC=C2C(=O)O)…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Also known as divinatorin A synthase (SdDAS).

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vivo
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Organic acids
Product class: Other

Literature & public identifiers

PubMed: PMID:41872198 ↗
DOI: 10.1038/s41467-026-70885-3 ↗
UniProt: A0ABD1I2D5 ↗
GenBank: —
NCBI TaxID: 28513 ↗

Comparative genome analysis provides a foundation for defining salvinorin A biosynthesis in Salvia divinorum.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme