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Silver mismatch Hydroxylation

CYP716C11

Centella asiatica CYP716C

Apiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
ursolic acid
PubChem ↗ C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C…
CYP716C11
ΔMass: +31.9898 Da mismatch
Product
asiatic acid
PubChem ↗ C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Mediates specific hydroxylation at C-2α position; used in combination with CaCYP714E19 for asiatic acid synthesis.

Reaction & quality gates

Mechanism
Hydroxylation
Evidence type
In vitro
Confidence
High
Data tier
Silver
mass=mismatch
Substrate class
Organic acids
Product class
Organic acids

Literature & public identifiers

PubMed
PMID:41799686 ↗
DOI
10.1016/j.synbio.2026.01.030 ↗
UniProt
A0A1I9Q5Y7 ↗
GenBank
NCBI TaxID
48106 ↗

Modular reconstruction and multilevel regulation of <i>Saccharomyces cerevisiae</i> to drive the efficient synthesis of asiatic acid.