Redox2

Tabernanthe iboga

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

19Z-geissoschizine

PubChem ↗ C/C=C/1\CN2CCC3=C([C@@H]2C[C@@H]1/C(=C/O)/C(=O)OC)NC4=CC=CC=C34

Redox2

ΔMass: -8.9508 Da mismatch

Product

19Z-16(R/S)-isositsirikine

PubChem ↗ CC/C=C\CC1OC1C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)[O-]

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ion; ion; TiRedox2 with 19Z-geissoschizine; products assigned by exact mass and MS2 with Z-shifted retention time.

Reaction & quality gates

Mechanism: Reduction
Evidence type: In vitro
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:41478566 ↗
DOI: 10.1016/j.jbc.2025.111120 ↗
UniProt: PX547881 ↗
GenBank: PX547881 ↗
NCBI TaxID: 141617 ↗

Conserved early steps of stemmadenine biosynthesis.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme