CYP71

Catharanthus roseus

Apocynaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

19E-geissoschizine

PubChem ↗ C/C=C\1/CN2CCC3=C([C@@H]2C[C@@H]1/C(=C/O)/C(=O)OC)NC4=CC=CC=C34

CYP71

ΔMass: -30.0106 Da cyp79_oximation(-30.0106)

Product

16-epi-pleiocarpamine

PubChem ↗ C/C=C\1/CN2CCC3=C4[C@@H]2C[C@@H]1[C@H](N4C5=CC=CC=C35)C(=O)OC

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CrGO also catalyzes minor C16-N1 bond formation to yield 16-formyl-pleiocarpamine, which deformylates to 16-epi-pleiocarpamine; confirmed by VIGS in planta.

Reaction & quality gates

Mechanism: CYP79 oximation (-30.01 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:40202182 ↗
DOI: 10.1002/anie.202501323 ↗
UniProt: W8JDE2 ↗
GenBank: —
NCBI TaxID: 4058 ↗

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme