CYP76AH1

Salvia miltiorrhiza CYP76A

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

miltiradiene

PubChem ↗ CC(C)C1=CCC2=C(C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C

CYP76AH1

ΔMass: +13.9793 Da mismatch

Product

ferruginol

PubChem ↗ CC(C)C1=C(C=C2C(=C1)CC[C@@H]3[C@@]2(CCCC3(C)C)C)O

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; CYP76AH1 from Salvia miltiorrhiza co-expressed with CPR1 in engineered Corynebacterium glutamicum; ferruginol production confirmed by GC-MS.

Reaction & quality gates

Mechanism: Hydroxylation
Evidence type: In vivo
Confidence: High
Data tier: Silver
mass=mismatch
Substrate class: Terpenoids
Product class: Other

Literature & public identifiers

PubMed: PMID:40108638 ↗
DOI: 10.1186/s12934-025-02691-3 ↗
UniProt: JX422213 ↗
GenBank: JX422213 ↗
NCBI TaxID: 226208 ↗

Bacterial biosynthesis of abietane-type diterpene ferruginol from glucose.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme