KO

Helliwell et

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

ent-kaurene

PubChem ↗ C[C@@]12CCCC([C@H]1CC[C@]34[C@H]2CC[C@H](C3)C(=C)C4)(C)C

ΔMass: +29.9742 Da methyl_to_carboxyl(+29.9742)

Product

ent-kaurenoic acid

PubChem ↗ C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@H](C3)C(=C)C4)(C)C(=O…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; PMID 38290048, 第5页: Helliwell et al. (1998) demonstrated that GA3 encodes KO based on accumulation of ent-kaurene in ga3-1 mutant and inability to respond to ent-kaurene application; KO activity confirmed after expression in yeast.

Reaction & quality gates

Mechanism: Oxidation
Evidence type: In vitro
Confidence: High
Data tier: Quarantine
PDF audit quarantine (enzyme_miss_in_pdf;two_core_fields_in_text;review_structured_partial_core). pdf=38290048.pdf; enzyme_in_pdf=miss; issue=review_structured…
Substrate class: Terpenoids
Product class: Organic acids

Literature & public identifiers

PubMed: PMID:38290048 ↗
DOI: 10.1093/plphys/kiae044 ↗
UniProt: A0A0U2SME9 ↗
GenBank: —
NCBI TaxID: —

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