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Quarantine ΔMass ✓ Oxidation

CYP719A41

Corydalis yanhusuo CYP719A

Papaveraceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping
Substrate
(S)-tetrahydrocolumbamine
PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)OC
CYP719A41
ΔMass: -2.0157 Da ketone_formation(-2.0157)
Product
(S)-tetrahydroberberine
PubChem ↗ COC1=C(C2=C(C[C@H]3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Efficient conversion >40%.

Reaction & quality gates

Mechanism
Ketone formation (-2.02 Da)
Evidence type
In vitro
Confidence
High
Data tier
Quarantine
PDF audit quarantine (enzyme_miss_in_pdf;two_core_fields_in_text;review_structured_partial_core). pdf=36737755.pdf; enzyme_in_pdf=miss; issue=review_structured…
Substrate class
Other
Product class
Alkaloids

Literature & public identifiers

PubMed
PMID:36737755 ↗
DOI
10.1186/s12934-023-02024-2 ↗
UniProt
GenBank
NCBI TaxID
458692 ↗

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production.