AaOSC2

Ailanthus altissima

Simaroubaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

2,3-oxidosqualene

PubChem ↗ CC(=CCC/C(=C/CC/C(=C/CC/C=C(\C)/CC/C=C(\C)/CCC1C(O1)(C)C)/C)/C)C

AaOSC2

ΔMass: +0.0000 Da mismatch

Product

tirucalla-7,24-dien-3β-ol

PubChem ↗ C[C@@H](CCC=C(C)C)[C@@H]1CC[C@]2([C@]1(CC[C@H]3C2=CC[C@@H]4[C@@…

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ization; ization; Confirmed by NMR after transient expression in Nicotiana benthamiana with booster genes.

Reaction & quality gates

Mechanism: Cyclization
Evidence type: In vivo
Confidence: High
Data tier: Quarantine
non-CYP auxiliary enzyme (pathway partner, not cytochrome P450)
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:36082289 ↗
DOI: 10.3389/fpls.2022.958138 ↗
UniProt: ON595696 ↗
GenBank: ON595696 ↗
NCBI TaxID: 2768810 ↗

Identification of early quassinoid biosynthesis in the invasive tree of heaven (<i>Ailanthus altissima</i>) confirms evolutionary origin from protolimonoids.