Sm2OGD25

Salvia miltiorrhiza

Lamiaceae

Substrate reaction site Product reaction site MCS substructure diff highlighting · RDKit atom mapping

Substrate

sugiol

PubChem ↗ CC(C)C1=C(C=C2C(=C1)C(=O)C[C@@H]3[C@@]2(CCCC3(C)C)C)O

Sm2OGD25

ΔMass: +15.9949 Da hydroxylation(+15.9949)

Product

hypargenin B

PubChem ↗ C[C@]12CCCC([C@@H]1CC(=O)C3=CC(=C(C=C23)O)C(C)(C)O)(C)C

Evidence trail

Excerpts are machine-extracted plain text for biochemical provenance. Follow DOI / PubMed links for the primary literature; publisher figures and PDF images are not displayed here.

Source text excerpt ation; ation; Sm2OGD25 catalyzes hydroxylation of sugiol at C-15 to produce hypargenin B, confirmed by in vitro enzyme assay with purified recombinant protein, UPLC-QTOF-MS, and NMR.

Reaction & quality gates

Mechanism: Hydroxylation (+15.99 Da)
Evidence type: In vitro
Confidence: High
Data tier: Gold
Latin binomial + experiment + dual SMILES + ΔMass pass
Substrate class: Other
Product class: Other

Literature & public identifiers

PubMed: PMID:35873989 ↗
DOI: 10.3389/fpls.2022.947674 ↗
UniProt: —
GenBank: —
NCBI TaxID: 226208 ↗

Functional Characterization of a 2OGD Involved in Abietane-Type Diterpenoids Biosynthetic Pathway in <i>Salvia miltiorrhiza</i>.

Evidence trail

Reaction & quality gates

Literature & public identifiers

Other reactions by this enzyme